Michele M Straus, Udi E Ghitza, Betty Tai Center for the Clinical Trials Network, National Institute on Drug Abuse, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, USA Abstract: The opioid overdose epidemic is an alarming and serious public health problem in the United States (US) that has been es
Communication for health promotion: history and identification of effective methods
This work aims to delineate the long journey of health communication, from the beginning to the present, stressing how the concept of health service and human health have been evolving together with the kind of political approach to the problem.First, the approach was mainly repressive and based on the surveillance of territory, so that jurisdictio
Post-translational regulation of Oct4 transcriptional activity.
Oct4 is a key component of the molecular circuitry which regulates embryonic stem cell proliferation and differentiation.It is essential for maintenance of undifferentiated, pluripotent cell populations, and accomplishes these tasks by binding DNA in multiple heterodimer and homodimer configurations.Very little is known about how formation of these
Spinocerebellar ataxias: from pathogenesis to recent therapeutic advances
Spinocerebellar ataxia is a phenotypically and genetically heterogeneous group of autosomal dominant-inherited degenerative disorders.The gene mutation spectrum includes dynamic expansions, point mutations, duplications, insertions, and deletions of varying lengths.Dynamic expansion is the most common form of Mop Handles mutation.Mutations often re